Search results for "Parametric modeling"
showing 4 items of 4 documents
A Time-to-Event Model for Acute Kidney Injury after Reduced-Intensity Conditioning Stem Cell Transplantation Using a Tacrolimus- and Sirolimus-based …
2017
There is a paucity of data evaluating acute kidney injury (AKI) incidence and its relationship with the tacrolimus-sirolimus (Tac-Sir) concentrations in the setting of reduced-intensity conditioning (RIC) after allogeneic stem cell transplantation (allo-HSCT). This multicenter retrospective study evaluated risk factors of AKI defined by 2 classification systems, Kidney Disease Improving Global Outcome (KDIGO) score and "Grade 0-3 staging," in 186 consecutive RIC allo-HSCT recipients with Tac-Sir as graft-versus-host disease prophylaxis. Conditioning regimens consisted of fludarabine and busulfan (n = 53); melphalan (n = 83); or a combination of thiotepa, fludarabine, and busulfan (n = 50). …
Design and Digital Fabrication of a Parametric Joint for Bamboo Sustainable Structures
2019
The study deepens the design of a joining system for bamboo spatial structure by proposing new and advanced solutions that guarantee maximum freedom of composition to the designer. The joint allows to determine and control parametrically the adaptability to any spatial grid configuration of culms with heterogeneous dimensions. Despite the bamboo being one of the main natural building materials in the field of sustainable architecture, currently, it is not used enough due to the lack of adequate connection systems. Bamboo is a rapidly growing renewable resource, naturally available, which is quite strong and lends itself to structural applications. The paper proposes an innovative approach t…
Algorithmic modeling and prototyping of a structural joint for freeform surfaces
2016
This paper describes a parametric approach in architectural design through the elaboration of a process for generating non-standard structural joints particularly suitable for the arrangement of freeform surfaces in which maximum adaptability of the system is required to join a different number of members converging in a node from generic directions. The algorithmic definitions, developed using the graphical editor Grasshopper integrated with Rhinoceros, allow the management of an integrated workflow from the conceptual design of freeform surface to the prototyping of a structural joint with 3D printing techniques.
Methodological aspects for the use of surfaces parametric modelers in architectural design. A study case
2017
Il presente studio affronta le implicazioni metodologiche determinate nello svolgimento di un iter progettuale tramite utilizzo di un modellatore parametrico algoritmico. L’obiettivo è quello di dimostrare come la parametrizzazione degli elementi morfologici debba generare un rapporto biunivoco con le logiche progettuali, ma senza dettarne le direttive o stravolgerle. Oggetto dell’intervento progettuale è un centro polifunzionale a vocazione turistica di servizio all’area del Parco Archeologico di Agrigento, che instauri con la Valle dei Templi un rapporto contestuale di dialogo morfologico e visivo. The present study addresses the methodological implications determined in the carrying out …